The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.
Moment closure in a Moran model with recombination
The waiting time for m mutations
Moran model with strong selection and $Λ$-Wright-Fisher SDE
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