{
  "id": "1306.6919",
  "version": "v1",
  "published": "2013-06-28T18:08:24.000Z",
  "updated": "2013-06-28T18:08:24.000Z",
  "title": "The waiting time for a second mutation: an alternative to the Moran model",
  "authors": [
    "Rinaldo B. Schinazi"
  ],
  "doi": "10.1016/j.physa.2014.01.031",
  "categories": [
    "math.PR",
    "q-bio.PE"
  ],
  "abstract": "The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.",
  "revisions": [
    {
      "version": "v1",
      "updated": "2013-06-28T18:08:24.000Z"
    }
  ],
  "analyses": {
    "keywords": [
      "moran model",
      "second mutation",
      "waiting time",
      "alternative",
      "appearance"
    ],
    "tags": [
      "journal article"
    ],
    "publication": {
      "journal": "Physica A Statistical Mechanics and its Applications",
      "year": 2014,
      "month": "May",
      "volume": 401,
      "pages": 224
    },
    "note": {
      "typesetting": "TeX",
      "pages": 0,
      "language": "en",
      "license": "arXiv",
      "status": "editable",
      "adsabs": "2014PhyA..401..224S"
    }
  }
}