Hopf bifurcation analysis of pathogen-immune interaction dynamics with delay kernel

M. Neamtu, L. Buliga, F. R. Horhat, D. Opris, A. T. Ceausu

Published 2006-10-23Version 1

The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of many kinds of infectious diseases. In the study of mathematical models of infectious diseases it is important to predict whether the infection disappears or the pathogens persist. The delay kernel is described by the memory function that reflects the influence of the past density of pathogen in the blood. By using the coefficient of kernel k, as a bifurcation parameter, the models are found to undergo a sequence of Hopf bifurcation. The direction and the stability criteria of bifurcation periodic solutions are obtained by applying the normal form theory and the center manifold theorems. Some numerical simulation examples for justifying the theoretical results are also given.