Bifurcations in Boolean Networks

Chris J. Kuhlman, Henning S. Mortveit, David Murrugarra, V. S. Anil Kumar

Published 2011-08-15, updated 2011-10-18Version 2

This paper characterizes the attractor structure of synchronous and asynchronous Boolean networks induced by bi-threshold functions. Bi-threshold functions are generalizations of classical threshold functions and have separate threshold values for the transitions 0 -> 1 (up-threshold) and 1 -> 0 (down-threshold). We show that synchronous bi-threshold systems may, just like standard threshold systems, only have fixed points and 2-cycles as attractors. Asynchronous bi-threshold systems (fixed permutation update sequence), on the other hand, undergo a bifurcation: when the difference \Delta of the down- and up-threshold is less than 2 they only have fixed points as limit sets. However, for \Delta >= 2 they may have long periodic orbits. The limiting case of \Delta = 2 is identified using a potential function argument. Finally, we present a series of results on the dynamics of bi-threshold systems for families of graph classes.