Identification of the Isotherm Function in Chromatography Using CMA-ES

Mohamed Jebalia, Anne Auger, Marc Schoenauer, Francois James, Marie Postel

Published 2007-10-01Version 1

This paper deals with the identification of the flux for a system of conservation laws in the specific example of analytic chromatography. The fundamental equations of chromatographic process are highly non linear. The state-of-the-art Evolution Strategy, CMA-ES (the Covariance Matrix Adaptation Evolution Strategy), is used to identify the parameters of the so-called isotherm function. The approach was validated on different configurations of simulated data using either one, two or three components mixtures. CMA-ES is then applied to real data cases and its results are compared to those of a gradient-based strategy.