{
  "id": "1507.01071",
  "version": "v1",
  "published": "2015-07-04T05:41:05.000Z",
  "updated": "2015-07-04T05:41:05.000Z",
  "title": "Approximation of the first passage time density of a Brownian motion to an exponentially decaying threshold by two-piecewise linear threshold. Application to neuronal spiking activity",
  "authors": [
    "Massimiliano Tamborrino"
  ],
  "comment": "17 pages, 7 figures",
  "categories": [
    "math.PR"
  ],
  "abstract": "The first passage time density of a diffusion process to a time varying threshold is of primary interest in different fields. Here we consider a Brownian motion in presence of an exponentially decaying threshold to model the neuronal spiking activity. Since analytical expressions of the first passage time density are not available, we propose to approximate the curved boundary by means of a continuous two-piecewise linear threshold. Explicit expressions for the first passage time density towards the new boundary are provided. Then we introduce different approximating linear threshold and describe how to choose the optimal one minimizing the distance to the curved boundary and hence the error in the corresponding passage time density. Theoretical means, variances and coefficients of variation given by our method are then compared with empirical quantities from simulated data as well as other firing statistics derived under the assumption of a small amplitude of the time-dependent change in the threshold. Finally maximum likelihood and moment estimators of the parameters of the Wiener process are also proposed and compared on simulated data.",
  "revisions": [
    {
      "version": "v1",
      "updated": "2015-07-04T05:41:05.000Z"
    }
  ],
  "analyses": {
    "subjects": [
      "60G40",
      "62M86",
      "60J70",
      "60J65",
      "60J60"
    ],
    "keywords": [
      "first passage time density",
      "neuronal spiking activity",
      "two-piecewise linear threshold",
      "exponentially decaying threshold",
      "brownian motion"
    ],
    "note": {
      "typesetting": "TeX",
      "pages": 17,
      "language": "en",
      "license": "arXiv",
      "status": "editable"
    }
  }
}